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Doctoral position in Medical Science
Project title: Molecular Mechanisms of Neurodevelopmental Disease
The Department of Laboratory Medicine, is located at the Institute of Biomedicine at the Faculty of Medicine at Sahlgrenska Academy, University of Gothenburg.
General information about being a doctoral student at the University of Gothenburg can be found on the university's doctoral student pages https: // medarbetarportalen.gu.se/doktorand/?languageId=100001&skipSSOCheck=true
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https: // www. gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Diseases that result from deleterious genetic variants in a single gene are individually rare and hence referred to as ‘rare genetic diseases' (RGDs). They are however collectively not uncommon as there are thousands of different genes and conditions described. Many RGDs impair normal brain development and result in life-long disabilities. Specific treatments are often lacking and clinical trials unfeasible for the many conditions with only a few patients reported. Whole-genome sequencing has revolutionised RGD diagnostics but there is an unmet need to experimentally assess the functional impact of identified variants.
This project will use cellular models of a number of understudied or "new" congenital diseases to establish genotype-phenotype associations and study disease mechanisms. In part, skin cells from specific patients will be used. Alternatively, genetic variants mimicking those found in patients will be introduced into healthy cells, which will later be differentiated into neurons to elucidate disease mechanisms in relevant cell types. The results of this study will increase our understanding of the underlying biology and improve the diagnostics of certain rare diseases, which in the long run will pave way for future molecular therapies. For the PhD student, the project will offer a solid training in cell- and molecular biology, advanced cell culture techniques, genetics, experimental design and literature review.
We look for curious, driven individuals with a strong capacity for analytical and critical reasoning. Documented experience of working with advanced cell culture such as ES/iPS cells is advantageous. Good knowledge of written and spoken English. The candidate should be willing to work in a team to pursue his/her research. Personal suitability is of great importance.
Education at third-cycle level comprises four years of full-time study, and leads to a doctoral degree. As part of your employment as a doctoral student, you may have departmental duties corresponding to up to 20 % of full-time employment, distributed throughout your study period. Departmental duties usually consist of teaching at first- and second-cycle levels, but may also include research and administration.
Education at third-cycle level requires general eligibility and specific eligibility as set out in the general syllabus for the subject.
The general eligibility requirements for education at third-cycle level are: 1. having completed a degree at second-cycle level, or 2. the fulfilment of course requirements totalling at least 240 credits, of which at least 60 credits must be at second-cycle level, or 3. the acquisition of equivalent knowledge in some other way, either in Sweden or abroad.
Specific entry requirements for this subject, according to the general syllabus, are: having completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.
The selection of applicants who are considered to have the ability required to benefit from the study programme and who meet the general and specific eligibility requirements are assessed based on the following documented qualifications: - specific knowledge and skills within the subject area and related research fields - experience of scientific theory and relevant research methodology - scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.
Once you have been admitted for education at third-cycle level, you will be employed as a doctoral student at the University of Gothenburg. The provisions for employment as a doctoral student can be found in ordinance SFS 1993:100. Initial employment as a doctoral student may apply for a maximum of one year, and may be renewed by a maximum of two years at a time. A doctoral student may be employed as a doctoral student for a maximum of eight years, but the total period of employment may not be longer than the equivalent of full-time education at third-cycle level for four years.
Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Laboratory Medicine. Extent: 100%. First day of employment: as agreed.
The University applies a local agreement on salaries for doctoral students.
For more information about the project please contact the principal supervisor, Fredrik Sterky, Associate Professor, Institute of Biomedicine, phone: +46 709916886, e-mail: [email protected]
Union representatives at the University of Gothenburg can be found here: https: // www. gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande
You can apply to be admitted for education at third-cycle level via the University of Gothenburg's recruitment portal. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.
You must include the following, in pdf format
If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier .
If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.
For information on what you need to submit in order to fulfill the English language requirement see https: // www. universityadmissions.se/en/entry- requirements/english-language-requirements/
Applications must be received by: 2023-11-20Information for International Applicants
Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:
https: // www. gu.se/en/about-the-university/welcome-services https: // www. movetogothenburg.com/
The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.
Salaries are set individually at the University.
In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.