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Doctoral position in Medical Science
Project title: Molecular characterization of asthma – A translational approach
The Department of Internal Medicine and Clinical Nutrition, is located at the Institute of Medicine at the Faculty of Medicine at Sahlgrenska Academy, University of Gothenburg. At the Department research in several different areas are conducted, such as endocrinology, hematology, gastroenterology, hypertension, pulmonary medicine and allergology and clinical nutrition. Research is focused on body composition and energy metabolism. Research is conducted in close cooperation with health care at both the Sahlgrenska University Hospital and Mölndal hospital.
General information about being a doctoral student at the University of Gothenburg can be found on the university's doctoral student pages https: // medarbetarportalen.gu.se/doktorand/?languageId=100001&skipSSOCheck=trueDuties
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https: // www. gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Current challenges in asthma disease management are likely related to the high degree of heterogeneity of the disease. Inhaled corticosteroids, which decrease airway type 2 inflammation (‘T2-high'), are a mainstay of asthma treatment; however, many patients continue having exacerbations despite treatment, potentially because they have persistent ‘T2-high' or ‘T2-low' inflammation and other factors driving the immunopathology of disease. Epidemiological data from large asthma cohorts have identified an overrepresentation of poorly controlled asthma in distinct asthma groups. There is a unmet need to identify immune mechanisms in clinically well- characterized asthmatics.
In this research project, we have full access to a unique population-based asthma cohort, the WSAS with detailed clinical data, and to severe asthma patients from the allergy clinic at Sahlgrenska University Hospital. We have access to samples from both airways and blood in well-characterized asthma groups, allowing us to study the understudied ‘T2-low' asthma group in comparison with the ‘T2-high' asthma group. We will investigate gene expression and how these are regulated by microRNAs, small molecules that affect the protein content of the cells. We are using novel methodology such as PrimeFlow®, which allow us to measure miRNA by flow cytometry, single-cell analysis, NanoString (RNA analysis) and proteomics. In vivo animal models may also be used. Through integrating epidemiological, clinical, and mechanistic approaches, our translation research program has the potential to uncover significant new knowledge both regards to better understanding of the immunological basis of asthma and progressing efforts towards developing novel therapies.
It is desirable that the candidate has a background in laboratory medicine (for example biology, biomedicine, biotechnology, immunology or other equivalent education), preferably with previous experience of laboratory work focused on research. It is important that you are thorough, have a good ability to work in a team and that you can work independently. The work requires a good ability in English speech and writing, as the work environment is international. Great emphasis will be placed on personal suitability.
Education at third-cycle level comprises four years of full-time study, and leads to a doctoral degree. As part of your employment as a doctoral student, you may have departmental duties corresponding to up to 20 % of full-time employment, distributed throughout your study period. Departmental duties usually consist of teaching at first- and second-cycle levels, but may also include research and administration.Eligibility
Education at third-cycle level requires general eligibility and specific eligibility as set out in the general syllabus for the subject.
The general eligibility requirements for education at third-cycle level are: 1. having completed a degree at second-cycle level, or 2. the fulfilment of course requirements totalling at least 240 credits, of which at least 60 credits must be at second-cycle level, or 3. the acquisition of equivalent knowledge in some other way, either in Sweden or abroad.
Specific entry requirements for this subject, according to the general syllabus, are: having completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.Assessment criteria
The selection of applicants who are considered to have the ability required to benefit from the study programme and who meet the general and specific eligibility requirements are assessed based on the following documented qualifications: - specific knowledge and skills within the subject area and related research fields - experience of scientific theory and relevant research methodology - scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.
Documented experience of cell culture (both cell lines and primary cells), protein and RNA extraction, western blot, real-time PCR, histological techniques, ELISA and flow cytometry are meritorious. Furthermore, some experience in bioinformatics is desirable.Employment
Once you have been admitted for education at third-cycle level, you will be employed as a doctoral student at the University of Gothenburg. The provisions for employment as a doctoral student can be found in ordinance SFS 1993:100. Initial employment as a doctoral student may apply for a maximum of one year, and may be renewed by a maximum of two years at a time. A doctoral student may be employed as a doctoral student for a maximum of eight years, but the total period of employment may not be longer than the equivalent of full-time education at third-cycle level for four years.
Location: Sahlgrenska Academy, Institute of Medicine, Department of Internal Medicine and Clinical Nutrition. Extent: 100%. First day of employment: as agreed.
The University applies a local agreement on salaries for doctoral students.Contact information
For more information about the project please contact the principal supervisor, Madeleine Rådinger, Professor, Institute of Medicine, e-mail: [email protected]Unions
Union representatives at the University of Gothenburg can be found here: https: // www. gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokandeApplication
You can apply to be admitted for education at third-cycle level via the University of Gothenburg's recruitment portal. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.
You must include the following, in pdf format
If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier .
If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.
For information on what you need to submit in order to fulfill the English language requirement see https: // www. universityadmissions.se/en/entry- requirements/english-language-requirements/
Applications must be received by: 2023-02-21Information for International Applicants
Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:
https: // www. gu.se/en/about-the-university/welcome-services https: // www. movetogothenburg.com/
The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.
Salaries are set individually at the University.
In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.