The University of Gothenburg tackles society's challenges with diverse
knowledge. 53 500 students and 6 500 employees make the university a large and
inspiring place to work and study. Strong research and attractive study
programmes attract scientists and students from around the world. With new
knowledge and new perspectives, the University contributes to a better future.
Project title: Creating vascularization in 3D bioprinted tissue by Stromal
Vascular Fraction and fat derived stem cells
The PhD education in Medical Science comprises carrying out a scientific
project and completing at least 30 credits of courses at third-cycle level.
The doctoral student must also write a scientific compilation thesis or
monograph corresponding to at least 120 credits. For more information about
third-cycle studies at Sahlgrenska Academy, see
https: // www. gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: In recent years, 3D-bioprinting has emerged as a technology for
tissue biofabrication. The process represents a form of additive manufacturing
that employs bioinks harboring cells from the patient that are used for layer-
by-layer printing of a desired 3D shape. Using 3D-printed replacement tissue
potentially eliminates the disadvantages associated with using foreign
material; however, current 3D-printed grafts generally lack vascularization,
which severely restricts their size, given that they rely on diffusion to
provide oxygen and nutrients. The diffusion range varies from ~200 µm to ~250
µm, which means that a construct totally dependent on diffusion cannot be
thicker than 0.5 mm. This is likely the most critical obstacle to
3D-bioprinted constructs attaining clinical relevance.
This doctoral project has 4 specific aims, each corresponding to a tentative
publication as part of a final thesis.
Aim 1: To determine the maximum graft thickness compatible with adequate
nutrient and oxygen supplies when printing in a porous 3D grid as compared
with solid printing
Aim 2: To determine whether the maximum thickness can be increased by seeding
the grid pores with mature endothelial cells and/or EPCs from SVF.
Aim 3: To determine the maximum graft thickness compatible with adequate
nutrient and oxygen supplies when printing with microfractured fat tissue and
evaluate the formation of a vascular network formation in these grafts.
Aim 4: To determine whether a combination of microfractured fat and SVF or fat
derived stem cells can improve vascularization further.
The studies include preparation of SVF and stem cells from fat tissue, cell
sorting with FACS, cell culturing, 3D bioprinting, in vitro and in vivo
experiments with cells, tissues and 3D bioprinted constructs. The applicant
should to be able to directly work independently in a lab environment.
Third-cycle studies are equivalent to four year full-time and lead to a Degree
of Doctor. Those appointed to doctoral studentships shall primarily devote
themselves to their studies. Those appointed to doctoral studentships may,
however, work to a limited extent with educational tasks, research and
administration (departmental duties). Before a PhD degree has been awarded,
duties of this kind may not comprise more than 20 per cent of a full-time
To be eligible for third-cycle studies, the applicant must meet both the
general and specific entry requirements.
A person meets the general entry requirements for third-cycle studies if he
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits
of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in
Sweden or abroad
A person meets the specific entry requirements for third-cycle studies in
Medical Science if he or she has successfully completed the English B/6 course
or is considered to have acquired equivalent knowledge through previous
In selecting between applicants who meet the general and specific entry
requirements, their ability to benefit from third-cycle studies shall be taken
into account. The assessment shall attach particular importance to documented
- specific knowledge and skills within the subject area and related research
- experience of scientific theory and relevant research methodology
- scientific analysis and presentation verified through thesis, degree
project, scientific journals or the like.
Documented experience with applicable techniques such as 3D bioprinting with
hydrogels, cell culture, fluorescence microscopy, confocal laser microscopy,
TOF-SIMS and AFM are of value.
After admission to third-cycle studies you will be appointed to doctoral
studentship. Regulations for employment of doctoral students are given in SFS
1993:100. The initial appointment may apply for no longer than one year. An
appointment may be renewed for no more than two years at a time. A person may
be appointed to a doctoral studentship for a total of eight years. The total
employment period may, however, not exceed the time corresponding to full-time
third-cycle study for four years.
Location: Sahlgrenska Academy, Institute of Clinical Sciences, Department of
Plastic Surgery. Extent: 100%. First day of employment: as agreed.
Salaries for doctoral students are regulated in a local agreement at the
For further information regarding the position
For more information about the project please contact the principal
Lars Kölby, Professor, Institute of Clinical Sciences,
phone: +46-706451155, e-mail: email@example.com
Union representatives at the University of Gothenburg:
https: // www. gu.se/en/about-the-university/work-at-the-university-of-
Information for International Applicants
Choosing a career in a foreign country is a big step. Thus, to give you a
general idea of what we and Gothenburg have to offer in terms of benefits and
life in general for you and your family/spouse/partner please visit:
https: // www. gu.se/en/about-the-university/welcome-services
https: // www. movetogothenburg.com/
How to apply
In order to apply for a position at the University of Gothenburg, you have to
register an account in our online recruitment system. It is the responsibility
of the applicant to ensure that the application is complete in accordance with
the instructions in the job advertisement, and that it is submitted before the
You must include the following, in pdf format
Diploma and transcripts showing that you meet with the general entry
Proof of completion of English 6 course or the acquired equivalent
knowledge through previous studies
If your degree is from a university outside of Sweden, make sure that you
attach a diploma and full transcripts that makes assessing your degree easier
If your degree has not been verified by a Swedish authority you need to
provide contact details to the issuing university, registrar or similar, that
can verify the degree at our request.
For information on what you need to submit in order to fulfill the English
language requirement see https: // www. universityadmissions.se/en/entry-
Closing date: 2021-11-09
The University of Gothenburg promotes equal opportunities, equality and
Applications will be destroyed or returned (upon request) two years after
the decision of employment has become final. Applications from the employed
and from those who appeal the decision will not be returned.
In connection to this recruitment, we have already decided which recruitment
channels we should use. We therefore decline further contact with vendors,
recruitment and staffing companies.