Doctoral Researcher in the Field of Pharmacology and Toxicology (m/f/x)Ludwig Maximilians Universitaet Muenchen • Walther-Straub-Institut für Pharmakologie und Toxikologie • München

Germany Universities

Germany

October 1, 2022

Description

Open Positions 1

Time Span as soon as possible for 3 years Application Deadline 01 Oct 2022 Financing yes Type of Position

  • PhD - Individual Supervisor
  • Field of Research

  • Mathematics / Natural Sciences
  • Medicine
  • Subjects Pharmacology and Toxicology Description Your tasks and responsibilities:

    Misuse of highly potent opioids such as fentanyl and its derivatives (e.g. carfentanyl) became an increasing risk for individuals and public health in recent years. In fact, in 2019-20 more than 500,000 individuals died from opioid overdose in the USA alone. Despite this dramatically increasing health risk, no effective therapy is available. The candidate assigned to this position will have the unique opportunity to evaluate and analyze newly generated antibodies raised against fentanyl or its derivatives with regard to their ability to neutralize opioid binding to their receptors in vitro. Further, the candidate will analyze signaling pathways induced by opioids in various cell lines endogenously expressing opioid receptors. The position will be located at the LMU Munich and is part of a close interdisciplinary cooperation between the Bundeswehr Institute of Pharmacology and Toxicology (Munich), the German Cancer Research Center (DKFZ, Heidelberg) and the Walther Straub Institute of Pharmacology and Toxicology (Munich).

    Your tasks include the following:

    Establish a radio-ligand binding assay in order to analyze the inhibitory effects of antibodies on fentanyl-receptor binding. Thus, the unrestricted willingness to work with radio chemicals is necessary. Culture eukaryotic cells and analyze intracellular signaling pathways by cell biological, biochemical and molecular biochemical methods. Determine and analyze pharmacological parameters such KD or EC50 Values. Acquire independently in deep knowledge of the relevant literature. Generate large datasets in well-defined time lines. Regularly present her/his data in meetings with the co-operation partners or institute meeting in English language.

    Your qualifications:

    The candidate must have

    A master's degree in natural sciences (biology, chemistry, biochemistry, etc). Strong communication skills, and to be able to work both independently and team-oriented. Sufficient skills in the English language (both written and oral).

    The candidate should have

    First experiences with the handling of radio chemicals. Hand on skills in cell culture. First experiences in the analysis of signaling induced by transmembrane, G protein-coupled or even opioid receptors.

    Benefits:

    We offer an unique opportunity to attend a PhD position, which is central within an excellent network consisting of three outstanding institutions. Thus, the candidate will get insights and impact from distinct perspectives and various established researchers. We offer intense support during the promotion and aim at publishing the data in international high-impact journals.

    People with disabilities who are equally as qualified as other applicants will receive preferential treatment.

    Contact:

    Ludwig Maximilians Universitaet Muenchen Walther-Straub-Institut für Pharmakologie und Toxikologie Dr. Andreas Breit Goethestrasse 33 80336 Muenchen Phone: 004989218075755 Email: andreas.breit@lrz.uni-muenchen.de

    Working Language

  • English
  • German
  • Language of Dissertation

  • English
  • Required Documents

  • CV
  • Reports, certificates
  • Letter of Motivation
  • List of Publication
  • More Information https: // job- portal.lmu.de/jobposting/5ec63eed7474502660e07af72aae2a1a5d9d6f0b0?ref=homepage