Do you want to contribute to top quality medical research?
To be a doctoral student means to devote oneself to a research project under
supervision of experienced researchers and following an individual study plan.
For a doctoral degree, the equivalent of four years of full-time doctoral
education is required.
The research group
The student will be supervised by Dr. Charlotte Hedin (clinical
gastroenterology specialist at the Karolinska and PhD) and co-supervised by
Dr. Eduardo Villablanca, (a leader in the field of mucosal immunology, with
an emphasis in intestinal homeostasis and IBD). Dr. Hedin is currently
working at the Karolinska Hospital and has assisted to the creation of the
“Chronic inflammation European Gastrointestinal tract: From molecules to
treatment” project. Dr. Hedin is leading the clinical projects and have
obtained international funding for it.
The doctoral student will be located within the Villablanca group, which is
part of the Immunology and Allergy Division at the Department of Medicine,
Solna and is located at the Center of molecular Medicine (CMM). The
Villablanca lab has available all the equipment necessary for molecular and
cellular biology is available. The student will have access to FACS analyzer
and sorters, confocal microscopy and all the basic equipment to perform the
proposed research. The student will also have access to core facilities and
services at the department and SciLifeLab, which include sequencing, imaging,
informatics services and animal housing and maintenance. In addition, Dr.
Villablanca is the co-director of the single cell RNA sequencing (scRNAseq)
core at CMM, taking responsibility in the operation of the Chromium 10X drop-
based system. Our group works in an inspiring and interactive research
environment at the Karolinska University, Solna and has ongoing collaborative
projects with national and international colleagues.
The doctoral student project and the duties of the doctoral student
In this study plan, the student will gain insights into the mechanisms that
underlie IBD resolution to identify potential therapeutic strategies that
promote intestinal regeneration. This project provides an excellent
opportunity to combine clinical and experimental studies to investigate IBD
and generate relevant translational knowledge. Methodological techniques are
well stablished in collaboration with Dr. Villablanca, and patient recruitment
has already started under the supervision of Dr. Hedin.
The student will master experimental models of intestinal inflammation and
will acquire a deep understanding of mucosal immunology and bioinformatics. In
addition, the student will obtain comprehensive knowledge in molecular biology
and microscopy techniques, including analyses of human samples. The student
will also acquire a deep knowledge of IBD as well as demonstrate understanding
of ethics, project and experimental design, basic bioinformatics analysis and
laboratory work. The project includes integration of clinical data of IBD
patients' dietary intake, medications, other environmental exposures and body
composition with molecular data, giving the student possibility to develop
his/her skills in statistical and bioinformatics analyses. Finally, the
student will learn in vitro and ex vivo work by using human and mouse organoid
culture as well as human specimens. The student is expected to attend
international conferences and spend a period abroad (Broad Institute,
What do we offer?
A creative and inspiring environment full of expertise and curiosity.
Karolinska Institutet is one of the world's leading medical universities. Our
vision is to pursue the development of knowledge about life and to promote a
better health for all. At Karolinska Institutet, we conduct successful medical
research and hold the largest range of medical education in Sweden. As a
doctoral student you are offered an individual research project, a well-
educated supervisor, a vast range of elective courses and the opportunity to
work in a leading research group. Karolinska Institutet collaborates with
prominent universities from all around the world, which ensures opportunities
for international exchanges. You will be employed on a doctoral studentship
which means that you receive a contractual salary. Employees also have access
to our modern gym for free and receive reimbursements for medical care.
Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must
meet the following general (A) and specific (B) eligibility
requirements at latest by the application deadline.
It is your responsibility to certify eligibility by following the instructions
on the web page Entry requirements (eligibility) for doctoral education.
A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD
education if you:
have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
have acquired substantially equivalent knowledge in some other way in Sweden or abroad.
Follow the instructions on the web page Entry requirements (eligibility) for
If you claim equivalent knowledge, follow the instructions on the web page
Assessing equivalent knowledge for general eligibility for doctoral education.
B) Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD
education if you:
- Show proficiency in English equivalent to the course English B/English 6 at
Swedish upper secondary school.
Follow the instructions on the web page English language requirements for
Verification of your documents Karolinska Institutet checks the
authenticity of your documents. Karolinska Institutet reserves the right to
revoke admission if supporting documents are discovered to be fraudulent.
Submission of false documents is a violation of Swedish law and is considered
grounds for legal action.
(A) and (B) can only be certified by the documentation
requirement for doctoral education.
Skills and personal qualities
The applicant must be efficient, thorough, a good communicator in English
, have experience from laboratory work, communicating science in the format of
conferences and publications, be flexible and have collaborating skills and
enjoy working in an international and dynamic team. The applicant should have
a strong motivation to the study the field mucosal immunology and
understanding of IBD. Earlier involvement in mucosal immunology or human
and mouse IBD related research is a merit. The project requires high
organization skills and management of patient datasets as well as good
communication with clinicians and nurses.
The applicant must have good analytic skills and basic knowledge of some
statistical software for data analysis, preferably R. The applicant should
fulfil basic conditions to be able to work with bioinformatics analyses
that includes documented good and broad knowledge and understanding in
Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4
--Video about Karolinska Institutet, how we all work towards "a better
health for all" -
Submit your application and supporting documents through the Varbi recruitment
system. Use the button in the top right corner and follow the instructions. We
prefer that your application is written in English, but you can also apply in
Your application must contain the following documents:
- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)
A selection will be made among eligible applicants on the basis of the ability
to benefit from doctoral education. The qualifications of the applicants will
be evaluated on an overall basis.
Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral
studies in the subject.
All applicants will be informed when the recruitment is completed.
The employment is at the Department of Medicine, Solna. The Department
consists of twelve divisions and each division consists of several research
groups. This position is located within the research group of Eduardo
Villablanca, at the Immunology and Allegry division.
Want to make a difference? Join us and contribute to better health for
|Type of employment
|Number of positions
|Last application date
||01.Dec.2021 11:59 PM CET