Do you want to contribute to top quality medical research?
To be a doctoral student means to devote oneself to a research project under
supervision of experienced researchers and following an individual study plan.
For a doctoral degree, the equivalent of four years of full-time doctoral
education is required.
The research group
The doctoral student will be part of a research team who investigates how the
bacterial microbiota participates in cancer initiation and progression.
Specifically, we are interested in the molecular mechanisms which link
bacteria to alterations of the tumor suppressor p53 pathway, and ultimately to
The PhD student will be co-supervised by Assistant Professor Marie-Stéphanie
Aschtgen, Pr. Birgitta Henriques-Normark, both experts in infectious diseases
and Pr. Galina Selivanova, an expert in tumor biology.
The doctoral student project and the duties of the doctoral student
Recent studies have confirmed the role of genotoxin-producing bacteria in
tumorigenesis. However, why and how bacteria influence cancer is still poorly
understood. In this context, the doctoral project aims at understanding the
molecular mechanisms of cancer promotion by oncogenic bacteria both on the
host and bacterial side, using Klebsiella pneumoniae as a model.
The main goals of the projects are:
To investigate how bacterial genotoxins modulate the immune response and
affect host tumor suppressor pathways.
To understand how bacterial K. pneumoniae genotoxins contribute to the
hypervirulence phenotype associated to increased rates of colorectal
The doctoral student will design and perform the lab experiments needed,
including animal experiments, and will draft the manuscripts linked to the
project. Additionally, to the work directly related to the doctoral project,
the student is expected to contribute to the lab routine duties of the group.
Finally, the student will participate in group meetings and journal clubs, and
will have the opportunity to attend international conferences on the topic.
What do we offer?
A creative and inspiring environment full of expertise and curiosity.
Karolinska Institutet is one of the world's leading medical universities. Our
vision is to pursue the development of knowledge about life and to promote a
better health for all. At Karolinska Institutet, we conduct successful medical
research and hold the largest range of medical education in Sweden. As a
doctoral student you are offered an individual research project, a well-
educated supervisor, a vast range of elective courses and the opportunity to
work in a leading research group. Karolinska Institutet collaborates with
prominent universities from all around the world, which ensures opportunities
for international exchanges. You will be employed on a doctoral studentship
which means that you receive a contractual salary. Employees also have access
to our modern gym for free and receive reimbursements for medical care.
Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must
meet the following general (A) and specific (B) eligibility
requirements at latest by the application deadline.
It is your responsibility to certify eligibility by following the instructions
on the web page Entry requirements (eligibility) for doctoral education.
A) General eligibility requirement
You meet the general eligibility requirement for doctoral/third-cycle/PhD
education if you:
have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or
have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or
have acquired substantially equivalent knowledge in some other way in Sweden or abroad.
Follow the instructions on the web page Entry requirements (eligibility) for
If you claim equivalent knowledge, follow the instructions on the web page
Assessing equivalent knowledge for general eligibility for doctoral education.
B) Specific eligibility requirement
You meet the specific eligibility requirement for doctoral/third-cycle/PhD
education if you:
- Show proficiency in English equivalent to the course English B/English 6 at
Swedish upper secondary school.
Follow the instructions on the web page English language requirements for
Verification of your documents Karolinska Institutet checks the
authenticity of your documents. Karolinska Institutet reserves the right to
revoke admission if supporting documents are discovered to be fraudulent.
Submission of false documents is a violation of Swedish law and is considered
grounds for legal action.
(A) and (B) can only be certified by the documentation
requirement for doctoral education.
Skills and personal qualities
We are looking for a highly motivated, curious, and creative candidate, with a
background in Immunology or Cancer biology. Hands-on laboratory experience
with basic laboratory techniques (western blots, qPCR) and mammalian cell
culture is required. Previous experience in animal studies (mice) or gene
expression data (RNAseq) analysis are highly valued. Successful candidates
should be self-driven and passionate about the research themes developed in
the lab, have strong organizational skills, and be willing to be part of the
Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4
Submit your application and supporting documents through the Varbi recruitment
system. Use the button in the top right corner and follow the instructions. We
prefer that your application is written in English, but you can also apply in
Your application must contain the following documents:
- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)
A selection will be made among eligible applicants on the basis of the ability
to benefit from doctoral education. The qualifications of the applicants will
be evaluated on an overall basis.
Karolinska Institutet uses the following bases of assessment:
- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral
studies in the subject.
All applicants will be informed when the recruitment is completed.
https: // staff.ki.se/people/marie-stephanie-aschtgen
https: // ki.se/en/mtc/galina-selivanova-group
Want to make a difference? Join us and contribute to better health for
|Type of employment
|First day of employment
||According to agreement
|Number of positions
|Last application date
||31.Jan.2022 11:59 PM CET