Developing combinatorial immunotherapy for cancer
Last modification : Tuesday, September 13, 2022
Over the last years, it has become more and more clear that the immune system
plays an important role in the development and progression of cancer.
Therefore, the research philosophy of this lab is to unravel this complex
issue by monitoring the immune system in patients throughout the disease
course and during clinical trials (immune profiling). The next and
simultaneous step is the development of more specific and combined
immunotherapy in preclinical models, based on the information gathered in
patients. We believe these translational correlations are necessary for
optimal immunotherapy development. The initial focus of the lab was ovarian
cancer, but meanwhile we have broadened our research to three cancer types:
ovarian cancer, glioblastoma and uterine sarcoma.
Glioblastoma (GBM) represents an unmet medical need for our society.
Virtually all GBM patients succumb to their disease and an actual cure is
still missing. Many novel treatments have been proposed; however, they all
failed to prolong patients' survival despite promising preclinical results. In
this study, we aim at creating an innovative medicinal product, which is
composed of different oncolytic viruses (OVs). After evaluating in depth the
efficacy of all the available OVs ever tested in GBM, we will select a group
of OVs with high oncolytic efficacy towards the different subgroups of GBM to
capture better the heterogenous GBM. In a multi-model in vivo preclinical
research platform, we will combine them with the clinical standard of care
(surgical removal of the tumor, radiotherapy and chemotherapy). In addition,
we will develop a new device aimed at improving the delivery of the viruses to
the brain tumors thereby further increasing their efficacy. This approach
represents a true innovation in the landscape of GBM.
We are looking for a motivated PhD candidate that wants to find the cure for
cancer together with our existing team. You hold a biomedical sciences,
medicine or bio-engineering diploma and ideally you already have a FELASA B
certificate. You are not reluctant to animal experiments.
We offer you an exciting PhD position in a very enthusiastic team of
researchers. Our mission is to find a cure for cancer and to prolong the
survival of patients. We collaborate with several national and international
partners and with industry to find a solution. Thanks to our close
collaboration with clinical partners, the research focus is very translational
For more information please contact Prof. dr. An Coosemans, tel.: +32 16 37 36
41, mail: firstname.lastname@example.org.
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