Clinical Research Fellow – Understanding the pathogenesis of bleeding disorders in children

Royal College of Surgeons in Ireland

Ireland

September 29, 2021

Description

Post Date : 08-Sep-2021 Close Date : 29-Sep-2021

Title: Clinical Research Fellow – Understanding the pathogenesis of bleeding disorders in children

Department: School of Pharmacy and Biomolecular Sciences

Tenure: Specified purpose contract (up to Dec 2022)

Location: 123 St Stephen's Green, Dublin 2

Reporting to: Prof James O'Donnell

Salary: Research Fellow Level 3 Grade Level 1 starting at €55,811

Proposed Start Date: As soon as possible

About The Low Von Willebrand factor Ireland Cohort of Kids (LoVIC-K) study

Von Willebrand factor (VWF) is a plasma glycoprotein that plays critical roles in maintaining vascular haemostasis. Inherited deficiency of VWF occurs in approximately 1% of children and constitutes the most common inherited bleeding disorder (von Willebrand disease or VWD).

Large international cohort studies have provided insights into the pathophysiology underlying type I VWD, particularly in patients with significantly reduced plasma VWF levels (< 0.3U/ml). In contrast however, the molecular mechanisms that are responsible for causing reductions in plasma VWF levels remain poorly understood. Importantly, VWF gene mutations are rare in this cohort, and linkage analysis suggests that additional unknown genes are involved in modulating the reduction in plasma VWF levels. Since the pathophysiology underlying Low VWF remains largely undefined, diagnosis and clinical management of these children poses significant challenges.

The Low VWF Ireland Cohort of Kids (LoVIC-K) study is longitudinal and a follow-up paediatric study utilising an existing international collaborative network to: -

  • investigate the relationship between Low VWF levels and bleeding phenotype in children
  • determine the roles of VWF synthesis, secretion and clearance in modulating the Low VWF phenotype for each individual child
  • characterize the genetic basis underlying the Low VWF phenotype in children
  • characterise the variations in VWF glycans associated with Low VWF in children.
  • We anticipate the investigations to have direct clinical relevance in terms of optimizing future paediatric care.
  • The Clinical Research Fellow will play a key role in the LovicK study, overseeing the execution of the clinical program administration and daily management of the proposed plan of investigation.

    Application Process

    Please apply online no later than 5pm on the closing date of Wednesday 29th September 2021 with your CV and a Covering Letter.

    Interviews are expected to take place on the week commencing 11th October 2021.

    Informal Enquiries can be directed to Prof James O'Donnell at icvb@rcsi.com