Post Date : 08-Sep-2021 Close Date : 29-Sep-2021
Title: Clinical Research Fellow – Understanding the pathogenesis of
bleeding disorders in children
Department: School of Pharmacy and Biomolecular Sciences
Tenure: Specified purpose contract (up to Dec 2022)
Location: 123 St Stephen's Green, Dublin 2
Reporting to: Prof James O'Donnell
Salary: Research Fellow Level 3 Grade Level 1 starting at €55,811
Proposed Start Date: As soon as possible
About The Low Von Willebrand factor Ireland Cohort of Kids (LoVIC-K)
Von Willebrand factor (VWF) is a plasma glycoprotein that plays critical
roles in maintaining vascular haemostasis. Inherited deficiency of VWF occurs
in approximately 1% of children and constitutes the most common inherited
bleeding disorder (von Willebrand disease or VWD).
Large international cohort studies have provided insights into the
pathophysiology underlying type I VWD, particularly in patients with
significantly reduced plasma VWF levels (< 0.3U/ml). In contrast however,
the molecular mechanisms that are responsible for causing reductions in plasma
VWF levels remain poorly understood. Importantly, VWF gene mutations are rare
in this cohort, and linkage analysis suggests that additional unknown genes
are involved in modulating the reduction in plasma VWF levels. Since the
pathophysiology underlying Low VWF remains largely undefined, diagnosis and
clinical management of these children poses significant challenges.
The Low VWF Ireland Cohort of Kids (LoVIC-K) study is longitudinal and a
follow-up paediatric study utilising an existing international collaborative
network to: -
investigate the relationship between Low VWF levels and bleeding phenotype
determine the roles of VWF synthesis, secretion and clearance in
modulating the Low VWF phenotype for each individual child
characterize the genetic basis underlying the Low VWF phenotype in
characterise the variations in VWF glycans associated with Low VWF in
We anticipate the investigations to have direct clinical relevance in
terms of optimizing future paediatric care.
The Clinical Research Fellow will play a key role in the LovicK study,
overseeing the execution of the clinical program administration and daily
management of the proposed plan of investigation.
Please apply online no later than 5pm on the closing date of Wednesday 29th
September 2021 with your CV and a Covering Letter.
Interviews are expected to take place on the week commencing 11th October
Informal Enquiries can be directed to Prof James O'Donnell at firstname.lastname@example.org