Cell and Molecular Biology Team Leader (Senior Research Associate)
NB: Appointment to Senior Research Associate is subject to approval by the
Faculty Board of the Cambridge School of Clinical Medicine
The ALBORADA Drug Discovery Institute (ADDI), part of the University of
Cambridge CIMR Division of Translational Medicine (https:// cambridge-
ddi.alzheimersresearchuk.org/), is seeking an neuroscientist experienced in
cell and molecular biology to play a leading role in its established drug
discovery team working on dementia. The ADDI is part of a network of world-
class Drug Discovery Institutes, funded by Alzheimer's Research UK, forming
the Alzheimer's Research UK Drug Discovery Alliance. The work of the ADDI at
Cambridge is aimed at validating new drug targets and identifying potential
new drugs for the treatment of Alzheimer's disease as well as other forms of
The successful candidate will lead a team of cellular and molecular biologists
working on target validation and supporting drug discovery programmes. They
will develop and execute a range of functional assays in cells, including
neuronal models, to identify and validate novel targets/mechanisms of
potential therapeutic value against neurodegenerative disease pathologies. The
successful candidate will be expected to provide scientific leadership,
experimental and intellectual input across a range of drug discovery and
target validation projects as well as supervise junior staff. The position
demands an enthusiastic and proactive mindset, along with a demonstrable
ability to troubleshoot and optimise methods and an aptitude for data
The successful candidate will be required to have the following skills and
A PhD in Biology, Pharmacology or a neuro-related discipline (or
equivalent experience) and significant relevant experience in an
industrial or academic environment.
Experience in working with neuronal models.
Significant experience in the manipulation and analysis of gene/protein
function in mammalian cells, including gene transfer/RNAi
Experience with imaging and microscopy
Knowledge of handling large data sets from 96 and 384 well formats
An ability to provide scientific leadership and supervise junior staff.
Willingness to be intellectually involved in a range of drug discovery and
target validation projects.
Additional desirable attributes would be:
Background in neurodegenerative disease or the cerebral vascular system.
Experience implementing or supporting imaging assays on a high content
An understanding of machine learning.
Working with chemists and other biologists in a stimulating and collaborative
environment with leadership opportunities, the successful candidate will also
be encouraged to contribute to implementing new technologies and processes and
develop ideas for new therapeutic strategies and targets.
This post is full time, however we would consider applicants who wish to work
flexibly or for a minimum of 0.6 FTE.
Specific enquiries about the post may be addressed to Dr. John Skidmore
Fixed-term: The funds for this post are available until 31 July 2025 in the
Click the 'Apply' button below to register an account with our recruitment
system (if you have not already) and apply online.
Closing Date: 14 November 2021
Please ensure that you upload a covering letter and CV in the Upload section
of the online application. The covering letter should outline how you match
the criteria for the post and why you are applying for this role. If you
upload any additional documents which have not been requested, we will not be
able to consider these as part of your application.
Please include details of your referees, including email address and phone
number, one of which must be your most recent line manager.
Please quote reference SA28445 on your application and in any correspondence
about this vacancy.
The University actively supports equality, diversity and inclusion and
encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible
to live and work in the UK.
C.I.M.R. Division of Translational Medicine
8 October 2021
14 November 2021