Assistant researcher in toxin-antitoxin studies

Lund University
February 02, 2023
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Offerd Salary:Negotiation
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Contract Type:Other
Working Time:Full time
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Medicinska fakulteten, Institutionen för experimentell medicinsk vetenskap

Lund University was founded in 1666 and is repeatedly ranked among the world's top 100 universities. The University has around 46 000 students and more than 8 000 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

Lund University welcomes applicants with diverse backgrounds and experiences. We regard gender equality and diversity as a strength and an asset.

Description of the workplace

Our research group uses a combination of microbiological, biochemical and structural apprpoaches to study molecular mechanisms of protein synthesis (translation). One of the research directions in the lab is study of toxin- antitoxin (TA) systems of bacteria and bacteriophages. One of the novel TA toxins discovered in the lab are so-called toxSAS enzymes that inhibit bacterial growth though producing poisonous nucleotides 1 or inhibiting translation by modifying tRNA 2. Now we have established that toxSAS TAs can act as bacterial antiviral immunity systems protecting bacteria from bacteriophages 3. This project will focus on discovery of other TA-based mechanisms of phage immunity and uncover their molecular mechanisms. Phage defence systems are both fascinating from the basic science point of view, but also clearly clinically relevant: with phage therapy being an important alternative to antibiotics, understating the mechanisms that thwart it is crucial.

We are now looking for an assistant researcher fulltime and permanent with desired start date April 1st 2023 or upon agreement.

In our group we strive for a supportive, respectful and stimulating working environment that promotes personal and professional development for all members. The lab is fully equipped and operates in close collaboration with top research groups in Europe and USA.

References

  • Jimmy S. et al. Proc Natl Acad Sci U S A 117 , 10500-10510, (2020)
  • Kurata T. et al. Molecular Cell 81 , 3160-3170 e3169, (2021)
  • Zhang T. et al. Nature 612 (7938):132-140 (2022)
  • We offer

    Lund University is a public authority which means that employees get particular benefits, generous annual leave and an advantageous occupational pension scheme. Read more on the University website about being a Lund University employee Work at Lund University Lund University

    Work duties and areas of responsibility

    As an assistant researcher your main responsibility will be experimental studies of toxin-antitoxin systems. Specifically, you will be applying microbiological, biochemical and molecular biology approaches to uncover the mechanisms of toxicity of new TA systems. Other tasks related to running the research group can also be relevant. As research in the field is rapidly progressing internationally, part of the work effort will be dedicated to keeping abreast with research literature and new methods in the field.

    Qualifications

    Required qualifications:

  • The successful applicant should hold a doctoral degree in molecular biology / microbiology or corresponding.
  • Publications record in international journals.
  • Good skills in both written and spoken English.
  • Experience in microbiological, biochemical and molecular biology studies of toxin-antitoxin (TA) systems.
  • Experience in working with bacteriophages
  • Excellent communication in English
  • Personal skills are of importance. It is crucial that you are structured in your work and can work independently and have good social skills,

    Desired qualifications

  • Experience in ribosomal biochemistry
  • Experience in protein or/and RNA biochemistry
  • Further information

    This is a full time permanent position with desired start date April 1st 2023 or upon agreement. Probationary employment may be applied.

    How to apply

    Applications are to be submitted via the University's recruitment system. The application is to/should include a personal letter justifying your interest in the position and how it matches your qualifications. The application is to/should also include a CV and degree certificates.

    The Faculty of Medicine is a part of Lund University, and is responsible for education and research within medicine and healthcare. Our academic programs are closely linked with the healthcare system and are firmly anchored in the faculty's strong research tradition. Our research spans a broad field within experimental preclinical research, near-patient clinical research and health sciences research. The Faculty of Medicine, with its 1,800 employees and 2,700 students in Lund and Malmö, is a knowledge-intensive meeting place for students, teachers and researchers from all over the world.

    We kindly decline all sales and marketing contacts.

    Type of employment Permanent position

    Contract type Full time First day of employment April 1st 2023 or by agreement Salary Monthly salary Number of positions 1 Full-time equivalent 100 City Lund County Skåne län Country Sweden Reference number PA2023/161 Contact

  • Vasili Hauryliuk, Research group leader, +460706090493
  • Sofia Sönnerstedt, HR coordinator , +46462229876
  • Union representative

  • OFR/ST:Fackförbundet ST:s kansli, 046-2229362
  • SACO:Saco-s-rådet vid Lunds universitet, [email protected]
  • SEKO: Seko Civil, 046-2229366
  • Published 19.Jan.2023 Last application date 02.Feb.2023 11:59 PM CET

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