Assistant Professor – Translational advanced in vitro model systems for systems toxicology

Leiden University
January 16, 2023
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The Faculty of Science and the Division Drug Discovery and Safety of LACDR is looking for a: Assistant Professor – Translational advanced in vitro model systems for systems toxicology Vacancy number: 22-877

Scientific Context The division of Drug Discovery and Safety aims to uncover the molecular mechanisms of cellular signalling that defines drug efficacy as well as unanticipated adverse drug responses on critical normal target tissues. Drug efficacy is focused on candidate anticancer drug targets. Mechanistic understanding of adverse drug reactions is focused on liver and kidney injury, the major organs for toxicity. The approaches involve high throughput functional genomics screening in combination with phenotypic and signalling pathway reporter live single cell imaging. Genetic engineering is applied to establish fluorescent reporter cancer cell lines and human induced-pluripotent stem cell (hiPSC) models and human relevant mutations and knock outs. Omics technologies are applied to identify candidate signalling components and pathways for further mechanistic studies. Relevant advanced 3D human organoid model systems are integrated in the research and translation to clinical settings is established. The investigations are part of (inter)national research programs.

Key Responsibilities The assistant professor will scientifically contribute to the above research in the division and actively contribute to the scientific excellence and publication strategies. The candidate will support and guide both undergraduate and graduate students with their mechanism-based investigations. The candidate should contribute to the acquisition of research grants and scientific writing and (further) develop a successful research line in close relation to the overall objectives of the research program. Up to maximally fifty percent of the position will be devoted to the BSc and MSc program of Bio-Pharmaceutical Sciences, involving the coordination of teaching modules and supervision of internship research projects. The candidate will actively partner with a large team of assistant professors within the LACDR.

Selection Criteria • a PhD in molecular/cellular toxicology with a focus on cellular signalling • preferred background in high content screening and/or omics technologies • several years post-doc experience • enthusiastic and ambitious • independent thinker • expertise in advanced molecular biology techniques and cell signaling • excellence in teaching and experience in course development in a pre • excellent scientific writing skills • ideal soft skills to supervise undergraduate and graduate students • strong team player

Our faculty & Institute The Faculty of Science teaches more than 2,600 students in the context of 8 bachelor's and 11 master's programmes. Working at the Faculty of Science means being part of an exciting, dynamic scientific environment which sets high standards for its students, staff and support staff alike. The Faculty is known for its friendly and team-spirited atmosphere, which promotes mutual exchange of knowledge. For more information, see https: // www. science.leidenuniv.nl.

Terms and conditions We offer a full-time, 1 year term position, with the possibility for a permanent employment based on performance. Salary range from € 3.974 to € 5.439 gross per month (pay scale 11, depending on experience), in accordance with the Collective Labour Agreement for Dutch Universities). We aim to employ more women in areas where they are underrepresented. Women are therefore especially invited to apply. Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3 %), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break.

Information Enquiries can be made to professor Bob van de Water ([email protected]; +31-71-5276223). If you have any questions about the procedure, please contact the secretariat of the Division of Drug Discovery and Safety, Marjolijn Lugthart ([email protected]); +31-71-5276270). Information about the faculty of science can be found at https: // www. science.leidenuniv.nl/index.php/english/ and about Leiden University at https: // www. vacancies.leiden.edu/.

Applications To apply for this vacancy, please send an email to professor Bob van de Water ([email protected]) and the secretariat, Marjolijn Lugthart ([email protected]). Please ensure that you upload the following additional documents quoting the vacancy number: • motivation letter • Curriculum Vitae • 2 reference letters Only applications received before 16 January 2023 can be considered.

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