University of Wroclaw invites applications for the position of assistant professor (post-doc) at the Department of Chemical Biology at the Faculty of Biotechnology
No 116.2022.ZChB.WB of November 23, 2022
Institute/Department: Faculty of Biotechnology
Position: assistant professor (post-doc)
Type of position: research
Research area / discipline: medical sciences, biomedical engineering
Application deadline: December 23, 2022
Expected contest results: January, 2023
Envisaged job starting date: February 1, 2023
Employment period: one year (possible extension to three years)
Type of contract: full time
Salary monthly: 7296 -7608 brutto PLN
Applications are invited from those who fulfil the statutory requirements specified in the Higher Education Act from 20th July 2018 (Dz. U. z 2018 r., poz. 1668) and the statutes of the University of Wroclaw.
In the research area:
conducting experiments, results analysis, regular record keeping according to common standards
Preparation of reports, presentations and publications.
In the organizational area:
participation in faculty/department meetings
Employment under the National Science Center project of the OPUS project of the National Science Center (2021/43 / B / NZ1 / 02961), under the title " Structure and role of copper-zinc metallothioneins in the cellular buffering of copper and zinc ions ".
The principal investigator of the project is professor Artur Krężel.
The project concerns determining the mechanisms of the functioning of metallothioneins (a family of low-molecular polycysteine cellular proteins) as a molecular linker in the cellular homeostasis of zinc and copper ions. Zinc and copper are two essential metal micronutrients of the d-block, which in inorganic biochemistry are often treated independently, for example, due to redox properties, mode of transport, and cellular distribution. However, both metals are bound by metallothioneins, although the role of these proteins in copper binding is not fully understood. On the other hand, it is known that metallothioneins are crucial for ensuring an adequate level of these metals in the cell and are responsible for the proper functioning of numerous signaling pathways dependent on zinc and copper. Dysfunction of these pathways leads to numerous disorders resulting in pathogenic changes, including cancer. Metallothioneins (MT), although studied for years in terms of chemical and biochemical characteristics, have always been treated as homogeneous proteins saturated only with zinc, copper, or cadmium (spectroscopic zinc probe). However, more and more biological evidence indicates the essence of mixed complexes with zinc and copper. Therefore, the present project is about understanding the properties, structure, and stability and, above all, explaining the role of mixed Cu / Zn-MT complexes in the homeostasis of these two elements. We plan, among others explain whether the mixed forms of MT control the level of both elements independently of each other or whether they are proteins that connect the metabolism of these metals. Furthermore, the project aims to determine how the mixed forms of MT regulate the function of other zinc and copper-dependent proteins and the consequences of dysfunction of this regulation.
Our team has extensive experience working on metalloproteins, determining their structure, stability, and mechanisms of (un)folding and interaction with other biomolecules. We offer work on unique and very modern research equipment and a chance to learn about a wide range of techniques in spectroscopy, mass spectrometry, biological chemistry, molecular biology, peptide synthesis, protein production, and purification and to present our results at international scientific conferences.
CV should include the following note : I consent, within the meaning of Articles 4 and 7 of RODO, i.e. Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation) (Official Journal of the EU L of 4.05.2016, pp. 1-88), to the processing of my personal data by the University of Wroclaw, pl. Uniwersytecki 1, 50-137 Wroclaw, for the purpose of recruitment for employment at the University of Wroclaw. I am aware that the consent given may be withdrawn at any time in a manner appropriate to its giving.
All the documents should be send in the electronic form to the following address: email@example.com with the message title: „assistant professor (post-doc) 116ZChBWB”.
Information clause for persons participating in the recruitment process:
Pursuant to Article 13 of Regulation 2016/679 of the European Parliament and of the Council of the European Union of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data and repealing Directive 95/46/EC (General Data Protection Regulation, RODO), we inform you that:
You have the right to:
withdraw consent to the processing of personal data, without affecting the lawfulness of processing carried out on the basis of consent before its withdrawal,
make a complaint to the supervisory authority – the President of the Office for Personal Data Protection.
Providing personal data is voluntary, however, failure to provide data such as: first name(s) and surname, date of birth, place of residence (correspondence address), will result in inability to participate in the recruitment process.
More about the employer:
The University of Wrocław is among the largest and bests Polish universities, teaching more than 250 thousand students and employing about 2000 scientists (https: // uni.wroc.pl/en/). Wrocław city is a large, open and continuously developing city well communicated (airport, railways) with the world (https: // www. wroclaw.pl/en/).Contact Information