The Neuroscience Center of HiLIFE Helsinki Institute of Life Science
https: // www. helsinki.fi/en/hilife-neuroscience-center (HiLIFE-NC) invites
applications for a
A joint doctoral student position
in Prof. Helena Kilpinen and Dr. Olli Pietiläinen groups
The position is part of research program that aims to discover biological
mechanisms of neurodevelopmental and psychiatric disorders. The Pietiläinen
and Kilpinen groups combine functional genomic and experimental approaches in
human stem cell derived neuronal models to discover how genetic variation
impacts cellular processes and differential disease risk. The goal is to
convert genetic discoveries into biological function that could be translated
into improved treatments of the disorders of the brain.
The Kilpinen and Pietiläinen groups at the HiLIFE-NC and HiLIFE Institute for
Molecular Medicine https: // www. helsinki.fi/en/hilife-fimm (HiLIFE-FIMM) are
located at the Meilahti biomedical campus in Helsinki and are closely linked
with research groups at the Faculty of Biological and Environmental Sciences
https: // www. helsinki.fi/en/faculty-of-biological-and-environmental-sciences.
HiLIFE-NC and HiLIFE-FIMM offer an inspiring environment to solve fundamental
challenges of brain functions as part of the multidisciplinary HiLIFE
infrastructure https: // www. helsinki.fi/en/helsinki-institute-of-life-science
at the university of Helsinki. In the Pietiläinen and Kilpinen groups you will
be part of a striving scientific community utilizing state of the art
technologies in genomics and cell biology for scientific discoveries of the
brain. We are looking for highly motivated, determined and innovative
researcher to join our team.
We are seeking a Doctoral candidate to work on a multidisciplinary project
that utilizes human induce pluripotent stem cells (iPSC) to model cellular
processes involved in neurodevelopmental and neuropsychiatric disorders. The
primary goal is to use known genetic risk variants to identify intermediate
cellular phenotypes that underlie these disorders. To this end we apply high-
throughput genome-wide omics approaches, such as RNA sequencing, and
proteomics to identify differences in cellular process between cell lines from
carrier patients and controls. The genomic analyses are complemented by
targeted experiments, cellular assays and gene editing techniques in isogenic
cell lines. In addition, we will combine different experimental in vitro
settings with the omics approaches to understand molecular pathways involved
in neuronal maturation, synapse development, and function. The Ph.D. student
will be responsible for designing and conducting wet-lab experiments and
bioinformatic analysis in iPSC derived neuronal models under the supervision
of Drs. Kilpinen and Pietiläinen.
We are looking for a highly motivated and creative person with a primary
interest in genomic data analysis and experimental laboratory research work in
iPSC derived model systems. Candidates should have a MSc in bioinformatics,
cell biology, neurobiology, molecular biology or other related disciplines.
The ideal candidate will have experience in at least one of the aforementioned
areas, and a strong interest in the others. Previous knowledge in neuronal
differentiations, molecular cell biology, and/or large-scale genomic datasets,
and strong programming skills are considered an advantage.
The position is available from November 2021 onwards, or earlier, if required.
The position comes with a four-year fixed-term position, with a possibility of
extension. The position is dependent of acceptance in the University of
Helsinki Doctoral Programs and aims for a Ph.D. degree graduation. Trial
period of 6 months will be applied.
The salary will be based on level 2-3 of the demands level chart for teaching
and research personnel in the salary system of Finnish universities. In
addition, the appointee will be paid a salary component based on personal
performance with the overall starting salary amounting to approximately
2100-2500 EUR per month, depending on the qualifications and previous relevant
research experience of the candidate.
Please submit your application via the University of Helsinki Recruitment
System by clicking the ‘Apply for the position button' below. Internal
applicants (i.e. current employees of the University of Helsinki) should
submit their applications through the SAP HR portal. If you need support with
the recruitment system, please contact firstname.lastname@example.org.
Please attach the following documents to your application as a single PDF
- CV (including publications)
- cover letter (maximum 1 page) that details your past experience and
motivation for applying to the post.
- contact details of at least two references
The deadline for applications is November 30th, 2021. Interviews will be
conducted either in person or online.
For more information on the position, please contact Dr. Olli Pietiläinen
(email@example.com) or Dr. Helena Kilpinen
University of Helsinki
The University of Helsinki (UH), founded in 1640, is a vibrant scientific
community of 40,000 students and researchers. It is one of the leading
multidisciplinary research universities and ranks among the top 100
international universities in the world. It is currently investing heavily in
life sciences research. UH offers comprehensive services to its employees,
including occupational health care and health insurance, sports facilities,
and opportunities for professional development.
Helsinki Institute of Life Science
Helsinki Institute of Life Science (HiLIFE) is a new institute established
in 2017 that supports high quality life science research across the University
campuses and faculties. HiLIFE builds on existing strengths and new recruits
and partnerships to create an attractive international environment for
researchers to solve grand challenges in health, food, and environment. HiLIFE
coordinates research infrastructures in life sciences and provides research-
based interdisciplinary training.
HiLIFE -Neuroscience Center
The Neuroscience Center is an international research unit within Helsinki
Institute of Life Science (HiLIFE) of the University of Helsinki, a leading
Nordic university with a strong commitment to life science research. The
research focus of NC is on translational brain plasticity. We carry out
research relevant for the human brain both in health and disease, and during
development and aging, by applying versatile approaches and modern technology
platforms. NC aims at making fundamental discoveries about brain functions and
especially translate research findings into improvements in the treatment,
prevention and diagnosis of psychiatric and neurological disorders. The
research in NC spans across several scales from stem cell research and
molecular neuroscience to systems and cognitive neuroscience in both animal
and human models.The research groups of NC conduct research in neuroscience at
the highest international level and actively apply the results for the benefit
of the society. NC collaborates actively with other units of HiLIFE and
faculties of the University of Helsinki, Helsinki University Central Hospital,
and Neurocenter Finland.
Institute for Molecular Medicine Finland
The Institute for Molecular Medicine Finland (FIMM) is an international
research unit focusing on human genomics and personalised medicine at the
Helsinki Institute of Life Science (HiLIFE) of the University of Helsinki -
a leading Nordic university with a strong commitment to life science research.
As part of Academic Medical Center Helsinki in Meilahti campus FIMM
collaborates locally with the Faculty of Medicine, Helsinki University
Hospital and National Institute for Health and Welfare. FIMM is part of the
Nordic EMBL Partnership for Molecular Medicine, composed of the European
Molecular Biology Laboratory (EMBL) and the centres for molecular medicine
in Norway, Sweden and Denmark, and the EU-LIFE Community.